Effects of anti-TNF biologic drugs on uveitis severity in Behçet patients: systematic review and Meta-analysis.

IF 0.2 Q4 UROLOGY & NEPHROLOGY Journal of Clinical Urology Pub Date : 2022-05-18 eCollection Date: 2022-01-01 DOI:10.18240/ijo.2022.05.19

Somayeh Abolhasani, Alireza Khabbazi, Foroogh Hosseini, Shiva Gholizadeh-Ghaleh Aziz, Shahriar Alipour

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Abstract

Aim: To investigate effects of anti-TNF biologic drugs on uveitis severity (comparing visual acuity logMAR levels) in Behçet patients.

Methods: Three databases PubMed, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behçet's disease (BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted.

Results: The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis (with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies (28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity logMAR levels (MD=-1.5 IU/L, 95%CI: -2.1, -0.01).

Conclusion: Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.

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抗肿瘤坏死因子生物药对贝赫切特患者葡萄膜炎严重程度的影响：系统综述和 Meta 分析。

目的：研究抗肿瘤坏死因子（anti-TNF）生物药对贝赫切特病患葡萄膜炎严重程度的影响（比较视力对数）：方法：在 PubMed、Scopus 和 Web of Science 三个数据库中搜索符合要求的论文，重点关注抗肿瘤坏死因子-α 因子治疗贝赫切特病（BD）相关葡萄膜炎的情况。选择了抗肿瘤坏死因子药物治疗前后的研究。在确定本研究的检索策略后，提取了相关数据：在目标数据库中进行了初步搜索，共找到约 1458 篇文章。结果：在目标数据库中进行了初步搜索，共找到约 1458 篇文章，其中 15 篇文章被选中进行系统性审查，只有 12 篇文章符合 Meta 分析的纳入标准（包含视力数据）。有 5 项研究报告了生物治疗前后泼尼松龙的平均剂量（分别为 28.56 毫克/千克和 7.56 毫克/千克）。此外，初步结果表明，视敏度 logMAR 水平显著降低（MD=-1.5 IU/L，95%CI：-2.1，-0.01）：结论：生物药物可明显减少泼尼松龙的剂量，并影响视力值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Urology UROLOGY & NEPHROLOGY-

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0.60

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0.00%

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