Assessment of spraying characteristics of two nasal sprays containing framycetin

S. Gribanova, V. Yankova, O. Gobyzov, M. Ryabov, A. Karpova, S. Kedik, I. Udyanskaya, V. Grigorieva, I. I. Krasnyuk (jr.), T. Slonskaya, A.A. Zhukova
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Abstract

Objective. To compare spraying characteristics of two nasal sprays containing framycetin – Isofra and Tramicent Materials and methods. We used a silicone model of the nasal cavity (Koken Co. Ltd., Tokyo, Japan) to assess dose distribution of the drug inside the nose. Shadow photography was applied to analyze dynamic characteristics of spraying and the dispersed composition of spray particles. Results. Using a silicone model, we evaluated the dose distribution of the spray inside the nasal cavity. We compared dose distribution of two nasal sprays containing framycetin (Isofra and Tramicent) with full and half-full bottles. Shadow photography was applied to evaluate dynamic characteristics of these sprays, including total duration of spraying, duration of its individual phases, spraying angle, as well as dispersion characteristics, such as average particle size and particle size distributions. Conclusion. The experiments with a silicone nose model demonstrated that Isofra ensured a larger distribution area inside the nasal cavity compared to Terramycin, which suggests a better coverage of the nasal mucosa with Isofra. Comparison of dynamic spraying characteristics (including duration of spraying phases, spraying angle, and shape of the cone) between Isofra and Tramicent using shadow photography showed that Isofra ensured a more homogenous spraying coverage with fine particles. Comparison of the dispersion composition of the two sprays showed that most of the Isofra dose was sprayed with smaller drops than Tramicent, which indicates a better dispersion of Isofra. Our findings suggest that Isofra ensured high quality spraying and effective delivery of the medicine into the nasal cavity. Key words: framycetin, spray, silicone nose model, shadow photography, spray characteristics
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两种含真菌素鼻腔喷雾剂的喷雾特性评价
目标。比较两种含异氟拉霉素鼻喷雾剂的雾化特性。我们使用硅胶鼻腔模型(日本东京Koken公司)来评估药物在鼻内的剂量分布。采用阴影摄影法对喷雾的动态特性和喷雾颗粒的分散组成进行了分析。结果。使用硅胶模型,我们评估了喷雾在鼻腔内的剂量分布。我们比较了两种含framycetin鼻喷雾剂(Isofra和Tramicent)在满瓶和半满瓶时的剂量分布。采用阴影摄影法评价喷雾的动态特性,包括总喷射时间、各阶段持续时间、喷射角度以及平均粒径和粒径分布等分散特性。结论。硅胶鼻模型实验表明,与Terramycin相比,Isofra在鼻腔内的分布面积更大,这表明Isofra对鼻黏膜的覆盖更好。采用阴影摄影法对Isofra和Tramicent的动态喷涂特性(包括喷涂阶段持续时间、喷涂角度和锥形)进行比较,结果表明,Isofra能保证更均匀的细颗粒喷涂覆盖。两种喷雾剂的分散成分比较表明,大部分剂量的异戊异黄酮喷雾剂的滴度比曲美森小,表明异戊异黄酮的分散效果更好。我们的研究结果表明,Isofra保证了高质量的喷雾和有效的药物进入鼻腔。关键词:框架霉素,喷雾,硅胶鼻模型,阴影摄影,喷雾特性
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来源期刊
Voprosy Prakticheskoi Pediatrii
Voprosy Prakticheskoi Pediatrii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
50
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