Ulcerative colitis, hereditary thrombophilia and coronavirus infection as links in a chain: the clinical case of comorbidity in 12-year-old girl

Abstract

We present the clinical case of a 12-year-old girl with acute ulcerative colitis (UC), which was clinically manifested by blood in the stool, and genetic thrombophilia, which in turn was manifested by thrombotic changes in the veins of the left lower limb and clinically we faced with the swelling of the left leg. At the colonoscopy and histological examination of biopsies we established the pathological changes in the mucous membrane of the large intestine, on CT of the abdominal organs with contrast enhancement and ultrasound of the lower extremities found the venous thrombosis. The complexity of this clinical case is due to the difficulty of differential diagnosis of thrombotic complications of UC and hereditary thrombophilia.The main therapy for thrombosis causes a high risk of aggravation of hematological manifestations of UC, which required a long-term selection of suitable therapy that allowed the thrombotic masses to dissolve without gastrointestinal bleeding. The condition of patient was improved significantly against the background of therapy with sulfasalazine and heparin. Key words: genetic thrombophilia, heparin, colonoscopy, sulfasalazine, thrombosis, ulcerative colitis