Open-Structure Magnetic Particle Spectroscopy (OMPS): Feasibility Study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-13 DOI:10.1109/LMAG.2022.3142720

Chan Kim;Jiyun Nan;Jayoung Kim;Jong-Oh Park;Chang-Sei Kim

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引用次数: 1

Abstract

Magnetic nanoparticles (MNPs) have been widely used as effective agents for actuation and localization for targeted drug delivery. Especially for the localization of MNPs, magnetic particle imaging (MPI) has been developed to use magnetization generated by a magnetic field. However, most MPI systems use a bore-type structure, and there exist limitations in terms of working space, compatibility with surrounding medical devices, and being able to respond to emergency situations from a medical perspective. To address these issues, we present a novel, open-structure, magnetic particle spectroscopy (OMPS) technique. The structural design, theoretical background, and analysis of the OMPS are presented, and experiments are conducted to evaluate the OMPS. The experimental results indicate that the detection volume can be obtained as a cylindrical region of interest (ROI) of 50 mm × 50 mm × 25 mm, and the feasibility can be exhibited within the same or larger ROI with similar amounts of Resovist as used in previous MPI studies. The results demonstrate the promising potential for OMPS.

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开放结构磁粉光谱学（OMPS）：可行性研究

磁性纳米颗粒（MNPs）已被广泛用作靶向药物递送的致动和定位的有效试剂。特别是对于MNP的定位，已经开发了利用磁场产生的磁化的磁粉成像（MPI）。然而，大多数MPI系统使用孔型结构，并且在工作空间、与周围医疗设备的兼容性以及能够从医疗角度应对紧急情况方面存在局限性。为了解决这些问题，我们提出了一种新的、开放结构的磁性粒子光谱（OMPS）技术。介绍了OMPS的结构设计、理论背景和分析，并对其进行了实验评价。实验结果表明，检测体积可以作为50mm×；50毫米；25mm，并且可以在与先前MPI研究中使用的Resovist量相似的相同或更大的ROI内表现出可行性。研究结果证明了OMPS的潜力。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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