Probing into Therapeutic Anti-cancer Potential of Apigenin: Recent Trends and Future Directions.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics Recent patents on inflammation & allergy drug discovery Pub Date : 2019-01-01 DOI:10.2174/1872213X13666190816160240
Ajay Sharma, Abdul Ghani, K. Sak, H. Tuli, A. Sharma, W. Setzer, Sanjeev Sharma, A. Das
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引用次数: 25

Abstract

BACKGROUND Natural products represent a therapeutic charm for the treatment of inflammation-associated diseases. Flavonoids which are one of the special categories of such natural products, have previously shown promising therapeutic potential. OBJECTIVES The current review discusses about the synthetic preview and anti-inflammatory potential of apigenin along with the underlying molecular mechanism in chronic human diseases especially cancer. In addition, the relevant patents on therapeutic potential of apigenin have also been mentioned. METHODS Literature search was carried out using PubMed/Science, Google Scholar etc. which was further expended by the different combination of keywords: apigenin, inflammation, mechanism,therapeutic potential, cancer etc. Patent information was retrieved by searching the key terms: apigenin, inflammation, therapeutic potential from various databanks including Espacenet, Google patents, freepatent online and mendeley of WIPO, USPTO, SIPO, JPO, KIPO and EPO databases. CONCLUSION Studies related to the anti-inflammatory and anticancer potential of apigenin have been explored through this review article. Moreover, the patent analysis of apigenin has further strengthened its therapeutic role. Probing into the therapeutic properties of apigenin, further add value to this molecule in terms of its down regulation of major inflammatory and cancer associated signaling pathways. The article simultaneously would assist the scientific community to precisely understand the role of apigenin and design novel anti-cancer therapies.
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芹菜素抗癌治疗潜力的研究进展及展望。
背景:天然产品代表了治疗炎症相关疾病的治疗魅力。黄酮类化合物是这类天然产物的特殊类别之一,此前已显示出良好的治疗潜力。目的综述芹菜素的合成前景、抗炎作用及其在人类慢性疾病特别是癌症中的分子机制。此外,还介绍了芹菜素治疗潜力的相关专利。方法通过PubMed/Science、谷歌Scholar等进行文献检索,并以芹菜素、炎症、机制、治疗潜力、肿瘤等关键词的不同组合进行扩展。通过检索WIPO、USPTO、SIPO、JPO、KIPO和EPO数据库的Espacenet、谷歌专利、freepent online和mendeley等数据库的关键词:芹菜素、炎症、治疗潜力等专利信息。结论本文对芹菜素抗炎和抗癌作用的相关研究进行了综述。此外,芹菜素的专利分析进一步加强了其治疗作用。探索芹菜素的治疗特性,进一步增加该分子在下调主要炎症和癌症相关信号通路方面的价值。同时,这篇文章将帮助科学界准确理解芹菜素的作用,并设计新的抗癌疗法。
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来源期刊
CiteScore
3.90
自引率
0.00%
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0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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Meet Our Editorial Board Member Diagnosis of Allergic Reactions to Drugs Non-steroidal Anti-inflammatory Drugs Other Antimicrobial Drugs Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones
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