{"title":"The Use of AFP-Complexes to Induce Apoptosis in Cancer Cells~!2008-03-12~!2008-05-20~!2008-06-12~!","authors":"V. Pak","doi":"10.2174/1874079000802010012","DOIUrl":null,"url":null,"abstract":"An anticancer \"magic bullet\" should have both efficacy and specificity parts. We have used an effective Apop- tosis I nducer t o t rigger t he apoptosis. A lpha-fetoprotein w as us ed t o de liver A poptosis I nducers s pecifically t o cancer cells. The AFP-AI complex inhibited tumor growth in mice, enlarged mice life survival and has shown a 50% response in patients with metastatic colorectal cancer.","PeriodicalId":89032,"journal":{"name":"The open cancer journal","volume":"2 1","pages":"12-14"},"PeriodicalIF":0.0000,"publicationDate":"2008-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open cancer journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874079000802010012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
An anticancer "magic bullet" should have both efficacy and specificity parts. We have used an effective Apop- tosis I nducer t o t rigger t he apoptosis. A lpha-fetoprotein w as us ed t o de liver A poptosis I nducers s pecifically t o cancer cells. The AFP-AI complex inhibited tumor growth in mice, enlarged mice life survival and has shown a 50% response in patients with metastatic colorectal cancer.
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