{"title":"The Outward Rectifying Anions and Organic Osmolytes Conductance in Malaria-Infected Erythocytes: Myth or Reality?","authors":"C. Duranton, Tanneur Valerie, Tauc Michel","doi":"10.2174/1874196701104010003","DOIUrl":null,"url":null,"abstract":"Malaria-infected erythrocytes acquired New Permeability Pathways (NPPs) to meet the needs in nutrients and disposal of waste products of the intraerythocytic parasite development. The NPPs have been intensively studied for their putative interest as therapeutic targets for malaria treatment. Over the past 10 years, many electrophysiological studies have identified novel ion conductances (reflecting a part of the NPPs activities) in the host plasma membrane of Plasmodium falciparum-infected erythrocytes. In this article, we review the electrophysiological/biophysical properties of the malaria-induced outwardly rectifying anion conductance and compare this conductance to the other anion conductances and permeabilities already described in the literature.","PeriodicalId":38956,"journal":{"name":"Open Bioinformatics Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2011-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Bioinformatics Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874196701104010003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 0
Abstract
Malaria-infected erythrocytes acquired New Permeability Pathways (NPPs) to meet the needs in nutrients and disposal of waste products of the intraerythocytic parasite development. The NPPs have been intensively studied for their putative interest as therapeutic targets for malaria treatment. Over the past 10 years, many electrophysiological studies have identified novel ion conductances (reflecting a part of the NPPs activities) in the host plasma membrane of Plasmodium falciparum-infected erythrocytes. In this article, we review the electrophysiological/biophysical properties of the malaria-induced outwardly rectifying anion conductance and compare this conductance to the other anion conductances and permeabilities already described in the literature.
期刊介绍：
The Open Bioinformatics Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters, clinical trial studies and guest edited single topic issues in all areas of bioinformatics and computational biology. The coverage includes biomedicine, focusing on large data acquisition, analysis and curation, computational and statistical methods for the modeling and analysis of biological data, and descriptions of new algorithms and databases. The Open Bioinformatics Journal, a peer reviewed journal, is an important and reliable source of current information on the developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.
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