Gynaecological Lymphomas: Case Reports and Literature Review of Primary Extranodal Female Genital Tract and Breast Non-Hodgkin Lymphomas

Abstract

Primary extra nodal gynaecological lymphomas are rare, but their diagnosis is crucial since their treatment differs from the treatment of primary gynaecological malignancies. Throughout presentation of three case reports and a literature review, clinical, radiologic, pathologic and therapeutic aspects of primary extra nodal gynaecological lymphomas will be discussed. The first case is about a 50-yearsold woman diagnosed with a cervical DLBCL successfully treated with R-CHOP chemotherapy. The second case concerns 30-years-old, 3G 0P, woman diagnosed with endometrial lymphoma after a third spontaneous miscarriage. The third is an 80-years-old woman diagnosed with right breast cancer and simultaneous left MALT lymphoma. Large homogenous masses and unusual presentation mode, especially among young patients, should raise the attention towards lymphoma. Biopsy is the key examination for the diagnosis of lymphoma. Once primary extranodal gynaecological location is confirmed, treatment essentially consists of chemotherapy, with or without radiotherapy, and thus widely differs from the treatment of primary gynaecological tumors.