Anti-cancer effect of L-Glutaminase on acute lymphoblastic leukemia (Raji), breast cancer (MCF7) and colorectal cancer (A549) cell lines

Elaheh Madadi Hiyagh, Sah, M. Ravasan, F. Darvishi, A. Mokhtarzadeh, B. Baradaran
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Abstract

Cancer Science & Pediatrics 2019 Background: There are lots of treatments for cancer but always enzymes are the most efficient. Glutamine can be used to support proliferation in multiple ways. It is a proteinogenic amino acid, and can be act as a nitrogen donor for the synthesis of amino acids as well as nucleotides biosynthesis in cellular processes. The presence of L-glutaminase has been reported in various organisms, including animals, plants, and microorganisms except humans. It’s a treatment enzyme for ALL and L-glutaminase also has proved ineffectual for treatment solid tumours such as breast cancer and colorectal. In following research Yarrowia yeast glutaminase is used.
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l -谷氨酰胺酶对急性淋巴细胞白血病(Raji)、乳腺癌(MCF7)和结直肠癌(A549)细胞系的抗癌作用
背景:有很多治疗癌症的方法,但酶总是最有效的。谷氨酰胺可以通过多种方式支持细胞增殖。它是一种蛋白质原氨基酸,在细胞过程中可以作为氨基酸合成和核苷酸生物合成的氮供体。l -谷氨酰胺酶已被报道存在于各种生物中,包括动物、植物和微生物,除了人类。它是一种治疗ALL的酶,l -谷氨酰胺酶也被证明对治疗乳腺癌和结肠直肠癌等实体肿瘤无效。在接下来的研究中,使用酵母耶氏菌谷氨酰胺酶。
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