{"title":"Human subject with unexpected biodistribution of [11C]PK11195","authors":"A. Roivainen, K. Någren, J. Virta, J. Rinne","doi":"10.2174/1876388X01103010010","DOIUrl":null,"url":null,"abstract":"[N-Methyl11 C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide [ 11 C]PK11195 is a widely used radiopharmaceutical for in vivo assessment of translocator protein 18 kDa (TSPO) activity using positron emission tomography. Here we present an interesting case of unusual distribution of [ 11 C]PK11195, that is a lack of uptake in tissues known for high expression of the TSPO.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"3 1","pages":"10-11"},"PeriodicalIF":0.0000,"publicationDate":"2011-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open nuclear medicine journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876388X01103010010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
[N-Methyl11 C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide [ 11 C]PK11195 is a widely used radiopharmaceutical for in vivo assessment of translocator protein 18 kDa (TSPO) activity using positron emission tomography. Here we present an interesting case of unusual distribution of [ 11 C]PK11195, that is a lack of uptake in tissues known for high expression of the TSPO.
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