Epidemiological data of ovarian cancer in Vojvodina and south great plain region in Hungary in 2007-2012 period: Crossbiomark IPA PROJECT HUSRB/1203/214/091

Abstract

www.onk.ns.ac.rs/Archive Vol 21, No. 3-4, December 2013 INTRODUCTION It is estimated that there are 65,697 new cases of ovarian cancer and 41,448 deaths in Europe each year (1). Ovarian cancer is among the sixth leading cancers in Vojvodina and the fifth leading cause of cancer death among female population in Vojvodina according to Cancer Registry of Vojvodina in 2010 (2). Only one fourth of women present with localized disease at diagnosis. The majority of ovarian cancer cases are diagnosed at an advanced stage of disease (FIGO stage III-IV) (3). The prognosis for survival from ovarian cancer is largely dependent upon the extent of disease at diagnosis. Approximately 15% of patients are presented with disease confined to the ovaries and after surgery, their 5-year survival is more than 90%. A 5-year survival among patients with advanced disease (FIGO stage III-IV) is less than 30% (4). The etiology of ovarian cancer is poorly understood. Early diagnostic of ovarian cancer is mandatory. Still, there is not enough sensitive diagnostic tool for early detection that can be recommended. There are numerous methods that have been tested in the preoperative identification of adnexal masses suspicious for malignancy. The results of some trials have reported the efficacy of screening of asymptomatic women with annual measurement of CA 125 and transvaginal ultrasound examination but they have failed to demonstrate a reduction in mortality (5). Risk factors for developing ovarian cancer are numerous: ages (over 50), gene mutation (BRCA 1, BRCA 2, and Lynch II syndrome), geographic variations (higher incidence in North America, and North Europe), reproductive factors (nullipara, infertility), and hormonal factors (6). The most common histopathological type of ovarian cancer is epithelial cancer and the most common histological subtype is serous carcinoma (7). The clinical symptoms of early ovarian cancer are nonspecific such as abdominal pain, bloating, changes in bowel frequency, and urinary and/or pelvic symptoms (8-10). The aim of this study was to evaluate epidemiological data of newly diagnosed ovarian cancer from Hospital Registry for Malignant Disease in Oncology Institute of Vojvodina and Department of Oncotherapy, University of Szeged in South Great Plain region in Hungary, in the period 2007-2012.