Nanotechnology-based inhalation treatments for lung cancer: state of the art

IF 4.9 Q2 NANOSCIENCE & NANOTECHNOLOGY Nanotechnology, Science and Applications Pub Date : 2015-11-19 DOI:10.2147/NSA.S49052
J. Ahmad, S. Akhter, M. Rizwanullah, S. Amin, Mahfoozur Rahman, M. Ahmad, M. Rizvi, M. Kamal, Farhan Jalees Ahmad
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引用次数: 116

Abstract

Considering the challenges associated with conventional chemotherapy, targeted and local delivery of chemotherapeutics via nanoparticle (NP) carriers to the lungs is an emerging area of interest. Recent studies and growing clinical application in cancer nanotechnology showed the huge potential of NPs as drug carriers in cancer therapy, including in lung carcinoma for diagnosis, imaging, and theranostics. Researchers have confirmed that nanotechnology-based inhalation chemotherapy is viable and more effective than conventional chemotherapy, with lesser side effects. Recently, many nanocarriers have been investigated, including liposomes, polymeric micelles, polymeric NPs, solid lipid NPs, and inorganic NPs for inhalation treatments of lung cancer. Yet, the toxicity of such nanomaterials to the lungs tissues and further distribution to other organs due to systemic absorption on inhalation delivery is a debatable concern. Here, prospect of NPs-based local lung cancer targeting through inhalation route as well as its associated challenges are discussed.
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基于纳米技术的肺癌吸入治疗:最新进展
考虑到与传统化疗相关的挑战,通过纳米颗粒(NP)载体将化疗药物靶向和局部递送到肺部是一个新兴的研究领域。最近的研究和越来越多的癌症纳米技术临床应用表明,NPs作为药物载体在癌症治疗中的巨大潜力,包括肺癌的诊断、成像和治疗。研究人员已经证实,基于纳米技术的吸入化疗是可行的,而且比传统化疗更有效,副作用更小。近年来,人们研究了许多纳米载体,包括脂质体、聚合物胶束、聚合物NPs、固体脂质NPs和无机NPs,用于吸入治疗肺癌。然而,这种纳米材料对肺组织的毒性以及吸入后由于全身吸收而进一步分布到其他器官的毒性是一个有争议的问题。本文就nps吸入途径靶向治疗局部肺癌的前景及其面临的挑战进行了讨论。
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来源期刊
Nanotechnology, Science and Applications
Nanotechnology, Science and Applications NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
11.70
自引率
0.00%
发文量
3
审稿时长
16 weeks
期刊介绍: Nanotechnology, Science and Applications is an international, peer-reviewed, Open Access journal that focuses on the science of nanotechnology in a wide range of industrial and academic applications. The journal is characterized by the rapid reporting of reviews, original research, and application studies across all sectors, including engineering, optics, bio-medicine, cosmetics, textiles, resource sustainability and science. Applied research into nano-materials, particles, nano-structures and fabrication, diagnostics and analytics, drug delivery and toxicology constitute the primary direction of the journal.
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