{"title":"Dexketoprofen trometamol-loaded eudragit® rl 100 nanoparticle formulation, characterization and release kinetics","authors":"A. A. Öztürk, E. Yenilmez, Y. Yazan","doi":"10.23893/1307-2080.APS.05705","DOIUrl":null,"url":null,"abstract":"The particle size of the formulations was measured in the range of 475.5-798.7 nm. The droplet size distribution of the formulations was observed in the range of 0.349-0.395. These results showed that nanosized and monodispersed formulations were prepared. The drug content was found to be in the range of 35-38%. DT-loaded particles exhibited nanostructured and spherical shape. In vitro release studies showed extended release of DT. Release was found to fit Korsmeyer-Peppas kinetic model using DDSolver software program.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"19","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACTA Pharmaceutica Sciencia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23893/1307-2080.APS.05705","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 19
Abstract
The particle size of the formulations was measured in the range of 475.5-798.7 nm. The droplet size distribution of the formulations was observed in the range of 0.349-0.395. These results showed that nanosized and monodispersed formulations were prepared. The drug content was found to be in the range of 35-38%. DT-loaded particles exhibited nanostructured and spherical shape. In vitro release studies showed extended release of DT. Release was found to fit Korsmeyer-Peppas kinetic model using DDSolver software program.
期刊介绍：
Acta Pharmaceutica Sciencia (Acta Pharm. Sci.), formerly known as Bulletin of Pharmacy and Acta Pharmaceutica Turcica is a peer-reviewed scientific journal publishing current research and reviews covering all fields of pharmaceutical sciences since 1953. The original studies accepted for publication must be unpublished work and should contain data that have not been published elsewhere as a whole or a part. The reviews must provide critical evaluation of the state of knowledge related with the subject. All manuscripts has to be written in clear and concise English. Starting from 2016, the journal will be issued quarterly both in paper and on-line formates also publish special issues for national or international scientific meetings and activities in the coverage field.
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