Formulation and evaluation of acetylsalicylic acid suppositories using capra hircus (goat) fat and its binary blends

Abstract

A study has been made on the formulation and evaluation of Acetylsalicylic acid (ASA) suppositories using Goat fat (GF) and its binary blends with Palm Kernel oil and Liquid Paraffin. Cocoa butter was used as the standard reference suppository base. Rectal suppositories containing ASA (300 mg) in pre-calibrated mould were prepared by fusion method and evaluated for appearance, crushing strength, weight variation, melting point, liquefaction time, content uniformity and in-vitro release using standard procedures. Liquefaction or disintegration time (minutes) followed this order: ACB(4.40±0.84) AGF >AGL>ACB (p<0.05). Results obtained indicated that the bases used generally could be ranked in the order of GL > GP > GF > CB (p<0.05) in terms of favourable physicochemical properties investigated. The foregoing indicates that GL or GP has promising potential and could be a substitute suppository base in the formulation of ASA suppositories.