Influence of Ambient Air Pollution on Glutathione-S-Transferase Polymorphism Genes-Meta-Analysis

Abstract

Background: Glutathione-S-Transferase (GST) plays an important role in the detoxication mechanism of our organism but the homozygous deletion of these genes leads to the reduction or suppression of its activity. The aim of this meta-analysis is to evaluate the effect of pollution on GSTM1 and GSTT1 polymorphisms. Methods: Ten publications out of two thousand six hundred fifty nine were consulted using PubMed, Google Scholar, Ovid and the European Journal of Medical Research which related to this topic. All abstracts and publications have been taken into account without restriction of languages. The t-test was used to compare the data of the selected articles. Results: The overall analysis of the data shows that the null GSTM1 and GSTT1 genotype was observed at a higher frequency in the exposed subjects compared to control. Two studies reported that pollution has very significant effects on GSTM1 and GSTT1 but the others studies have shown no significant difference. Conclusion: Ambient air pollution has a negative impact on the expression of GST polymorphism as the deletion which could depend of type of pollutants and population. It would be interesting to conduct others studies to improve our knowledge in individual susceptibility according to the type of population and pollutants.