Intrathecal baclofen withdrawal: A rare cause of reversible cardiomyopathy*

Stephen O Awuor, Paul M. Kitei, Y. Nawaz, Amy M. Ahnert
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引用次数: 2

Abstract

Baclofen is commonly used to treat spasticity of central etiology. Unfortunately, a potentially lethal withdrawal syndrome can complicate its use. This is especially true when the drug is administered intrathecally. There are very few cases of baclofen withdrawal leading to reversible cardiomyopathy described in the literature. The authors present a patient with a history of chronic intrathecal baclofen use who, in the setting of acute baclofen withdrawal, develops laboratory, electrocardiogram, and echocardiogram abnormalities consistent with cardiomyopathy. Upon reinstitution of intrathecal baclofen, the cardiomyopathy and associated abnormalities quickly resolve. Although rare, it is crucial to be aware of this reversible cardiomyopathy to ensure its prompt diagnosis and treatment.
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鞘内巴氯芬戒断:可逆性心肌病的罕见病因*
巴氯芬常用于治疗中枢病因性痉挛。不幸的是,一种潜在的致命戒断综合症会使其使用复杂化。在鞘内给药时尤其如此。文献中很少有巴氯芬停药导致可逆性心肌病的病例。作者报告了一位有慢性鞘内巴氯芬使用史的患者,在急性巴氯芬戒断的情况下,出现了与心肌病一致的实验室、心电图和超声心动图异常。重新使用鞘内巴氯芬后,心肌病和相关异常迅速消退。虽然罕见,但了解这种可逆性心肌病以确保其及时诊断和治疗至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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