Supply of iron in piglets with colostrum/milk of sows using iron (IV) clatrochelate

I. Derkach, S. Derkach, V. Dukhnytsky, I. Fritsky, M. Plutenko
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引用次数: 1

Abstract

Many works of both Ukrainian scientists and foreign are devoted to the study of the prevention of iron deficiency anemia in piglets as one of the most common non-communicable diseases of pigs. However, the development of new effective antianemic drugs is still relevant today. We have previously proposed a scheme for the prevention of iron deficiency anemia, based on intramuscular parallel administration of solutions of iron (IV) clatrochelate and cyanocobalaminе to pregnant sows 14 and 7 days before the expected farrowing. This scheme was effective in the absence of stillbirth and clinical signs of anemia in piglets. The aim of our next study was to investigate the content of iron in the milk of sows using iron (IV) clatrochelate during pregnancy. To achieve this goal, 2 groups of sows (hybrids of Landrace and Great White breeds) were formed during their pregnancy and kept with suckling piglets - control and experimental, 5 animals in each. Sows in the experimental group were injected twice (14 and 7 days before expected farrowing) with 10 ml of 10% iron (IV) clatrochelate solution and cyanocobalaminе solution (at the dose recommended by official instructions) twice during pregnancy. Sows of the control group were injected with isotonic sodium chloride solution in conventional doses. During the experiment, the sows of the experimental group during pregnancy (after drug administration) and during the feeding of piglets did not differ in behavior and general condition from the sows of the control group. The study of the dynamics of hemoglobin and morphological parameters of the blood of sows in the control and experimental groups did not reveal significant differences. The content of iron in colostrum / milk of sows of the experimental group during the first seven days after administration was significantly higher compared to the control: 1 day 1.5 times, 4 days 2.1 times and 7 days 2.8 times. Therefore, the proposed scheme for the prevention of iron deficiency anemia in piglets is highly efficientand based on the intake of iron with colostrum/milk of sows. Key words: anemia, injection, macrobicyclic complex, prophylaxis, pigs, cyanocobalaminе.
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用螯合铁(IV)在仔猪初乳/母猪乳中添加铁
乌克兰科学家和外国科学家的许多工作都致力于研究预防仔猪缺铁性贫血,这是猪最常见的非传染性疾病之一。然而,开发新的有效的抗贫血药物在今天仍然具有重要意义。我们之前提出了一种预防缺铁性贫血的方案,基于肌内平行给药铁(IV)螯合铁和氰钴胺,妊娠母猪在预期分娩前14天和7天。该方案在仔猪无死产和贫血临床症状的情况下有效。我们下一项研究的目的是研究妊娠期间使用氯螯合铁(IV)的母猪奶中的铁含量。为了实现这一目标,在母猪怀孕期间形成两组母猪(长白种和大白种的杂交母猪),并与哺乳仔猪一起饲养-对照和实验,每组5头。试验组母猪在妊娠期间(预产期前14天和7天)分别注射10%氯螯合铁溶液和氰钴胺溶液10 ml(按官方说明书推荐剂量)。对照组母猪按常规剂量注射等渗氯化钠溶液。在试验期间,试验组母猪在妊娠期(给药后)和仔猪饲养期间的行为和一般状况与对照组母猪无显著差异。对对照组和试验组母猪血液中血红蛋白动态和形态参数的研究没有发现显著差异。试验组母猪初乳/乳铁含量在给药后第7天显著高于对照组:第1天1.5倍,第4天2.1倍,第7天2.8倍。因此,所提出的预防仔猪缺铁性贫血的方案是高效的,并且基于母猪初乳/乳中铁的摄入量。关键词:贫血,注射,大环复合物,预防,猪,氰钴胺
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