Early Resected Pancreatic Head Adenocarcinoma with Development of Sole Osteoblastic/Osteolytic Metastatic Disease: A Case Report and Review of the Literature

Abstract

Pancreatic adenocarcinoma is associated with high rates of mortality due to a high rate of recurrence even in early stage resected disease. Metastatic disease of the pancreas usually presents initially with spread to the surgical bed, liver, and lungs, and further metastatic disease to the bone is rare. Here, we present a case of pancreatic cancer recurrence with isolated osteoblastic and osteolytic bone metastasis without visceral organ spread in a patient with early stage resected pancreatic head adenocarcinoma. We review the literature for such cases and propose possible mechanisms and treatments.