Clinicopathological Properties of Mesenchymal Tumors of the Stomach and Surgical Treatment Outcomes

IF 0.4 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Iranian Red Crescent Medical Journal Pub Date : 2023-06-05 DOI:10.32592/ircmj.2023.25.6.2504
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Abstract

Background: Mesenchymal tumors are part of a heterogeneous group of neoplasms. Objectives: The present study investigated the clinicopathological properties and surgical outcomes of patients with gastric mesenchymal tumors who underwent surgical treatment. Methods: This study included all cases who underwent surgical treatment for mesenchymal tumors in Başakşehir Çam and Sakura City Hospital, Turkey, between August 2020 and August 2022. The demographic data and clinical properties of the patients, operative details, postoperative assessments, pathological specifications of the tumor, and immunohistochemical analysis results were evaluated. Results: The study included 14 patients, 57% of whom were male. Patients had a mean age of 59.7±9.3 years. The most frequent American Society of Anesthesiologists (ASA) score was ASA 2 in 10 (72%) patients, and the mean hemoglobin level was 12±1.9 g/dl. All patients underwent wedge resection, 5 (35.7%) by a minimally invasive method. The mean duration of operation was 98.9±29.4 min. There were no intraoperative complications, conversions, or postoperative mortalities, and the mean duration of hospital stay was 6.2±3.2 days. One patient made an unplanned re-admission to the hospital due to inadequate oral intake. As an adjuvant treatment, three patients were prescribed imatinib. The tumor location was most frequently the corpus in 5 (36%) patients, and the mean tumor diameter was 62±35.2 mm. Stromal tumors were the most common histological type in 10 (72%) patients, and the other histological types were leiomyoma in 3 (21%) and pancreatoblastoma in 1 (7%) patient. The median and maximum Ki-67 index were 3 and 80, respectively, and the median and maximum mitotic index were 3 and 18, respectively. The number of dissected lymph nodes was nine in one patient and five in another. The surgical margin was positive in one patient, and no patient had a perforated tumor. Conclusion: Among the different types of mesenchymal tumors of the gastrointestinal system, which are rare, stromal tumors are the most common histological type. Gastric mesenchymal tumors can be safely treated with wedge resection, an approach that is associated with low postoperative morbidity and mortality.
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胃间充质瘤的临床病理特征及手术治疗效果
背景:间充质肿瘤是异质性肿瘤的一部分。目的:探讨手术治疗胃间充质瘤的临床病理特点和手术效果。方法:本研究纳入了2020年8月至2022年8月期间在土耳其bauriak ehir Çam和Sakura市医院接受间充质肿瘤手术治疗的所有病例。对患者的人口学资料和临床特征、手术细节、术后评估、肿瘤病理特征和免疫组织化学分析结果进行评估。结果:纳入14例患者,男性占57%。患者平均年龄59.7±9.3岁。10例(72%)患者最常见的ASA评分为ASA 2,平均血红蛋白水平为12±1.9 g/dl。所有患者均行楔形切除术,其中5例(35.7%)采用微创方法。平均手术时间为98.9±29.4 min,无术中并发症、转诊及术后死亡,平均住院时间为6.2±3.2 d。一名患者因口服摄入不足而意外再次入院。作为辅助治疗,3例患者服用伊马替尼。5例(36%)患者肿瘤多发于体部,平均肿瘤直径为62±35.2 mm。10例(72%)患者以间质瘤为最常见的组织学类型,其他组织学类型为平滑肌瘤3例(21%)和胰腺母细胞瘤1例(7%)。Ki-67指数中位数和最大值分别为3和80,有丝分裂指数中位数和最大值分别为3和18。一名患者有9个淋巴结,另一名患者有5个淋巴结。一例手术切缘阳性,无一例肿瘤穿孔。结论:在胃肠道间质肿瘤的不同类型中,间质肿瘤是最常见的组织学类型。胃间充质肿瘤可以安全的采用楔形切除术治疗,这种方法术后发病率和死亡率低。
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来源期刊
Iranian Red Crescent Medical Journal
Iranian Red Crescent Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.16
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0.00%
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0
期刊介绍: The IRANIAN RED CRESCENT MEDICAL JOURNAL is an international, English language, peer-reviewed journal dealing with general Medicine and Surgery, Disaster Medicine and Health Policy. It is an official Journal of the Iranian Hospital Dubai and is published monthly. The Iranian Red Crescent Medical Journal aims at publishing the high quality materials, both clinical and scientific, on all aspects of Medicine and Surgery
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