Moein Yazdkhasti, M. Jalali, G. Khadjeh, H. Jafari, A. Rezaie
{"title":"Cardiotoxic Effects of Hemiscorpius Lepturus Scorpion Venom Fractions in Rats","authors":"Moein Yazdkhasti, M. Jalali, G. Khadjeh, H. Jafari, A. Rezaie","doi":"10.32598/IJT.15.1.691.1","DOIUrl":null,"url":null,"abstract":"Methods: The scorpion’s venom was extracted into six fractions by chromotagraphy. Healthy male Wistar rats (N=72) were equally divided into eight groups of nine: G1: Controls (0.5ml. normal saline), G2: Crude venom (1000μg/kg), G3: F-I (120μg/kg), G4: F-II (430μg/kg), G5: F-III (80 μg/kg), G6: F-IV (180μg/kg), G7: F-V (60μg/kg), and G8: F-VI (130μg/kg). Blood samples were obtained by cardiac puncture at 1, 3 and 24 hours after the venom injection. The serum levels of AST, LDH, CPK, CK-MB and troponin-I were determined. Upon euthanasia, the hearts were removed from the rats and examined microscopically for histopathology.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"27-36"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/IJT.15.1.691.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 3
Abstract
Methods: The scorpion’s venom was extracted into six fractions by chromotagraphy. Healthy male Wistar rats (N=72) were equally divided into eight groups of nine: G1: Controls (0.5ml. normal saline), G2: Crude venom (1000μg/kg), G3: F-I (120μg/kg), G4: F-II (430μg/kg), G5: F-III (80 μg/kg), G6: F-IV (180μg/kg), G7: F-V (60μg/kg), and G8: F-VI (130μg/kg). Blood samples were obtained by cardiac puncture at 1, 3 and 24 hours after the venom injection. The serum levels of AST, LDH, CPK, CK-MB and troponin-I were determined. Upon euthanasia, the hearts were removed from the rats and examined microscopically for histopathology.
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