M. Gürbüz, E. Akkuş, Bilgin Karaalioğlu, E. Aktaş, E. B. Köksoy, Hilal Özakıncı, S. Hayme, Y. Urun, S. Sak, A. Demirkazık, G. Utkan
{"title":"Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients","authors":"M. Gürbüz, E. Akkuş, Bilgin Karaalioğlu, E. Aktaş, E. B. Köksoy, Hilal Özakıncı, S. Hayme, Y. Urun, S. Sak, A. Demirkazık, G. Utkan","doi":"10.37047/JOS.2020-79248","DOIUrl":null,"url":null,"abstract":"EGFR is an important therapeutic target in lung adenocarcinoma.4 Oral tyrosine kinase inhibitors (TKIs) can be used in patients with driver mutations in EGFR.5 EGFR mutations were observed in ~1015% of NSCLC patients in Western populations and up to 50% in Asian populations.6,7 In a previous study, the EGFR mutation rate in adenocarcinomas was 33.9% for women and 9.4% for men in 499 cases, and the overall mutation rate was 14%.8 Also, EGFR mutations are more frequently detected in female patients and non-smokers.9","PeriodicalId":31838,"journal":{"name":"Journal of Oncological Sciences","volume":"7 1","pages":"20-24"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oncological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37047/JOS.2020-79248","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
EGFR is an important therapeutic target in lung adenocarcinoma.4 Oral tyrosine kinase inhibitors (TKIs) can be used in patients with driver mutations in EGFR.5 EGFR mutations were observed in ~1015% of NSCLC patients in Western populations and up to 50% in Asian populations.6,7 In a previous study, the EGFR mutation rate in adenocarcinomas was 33.9% for women and 9.4% for men in 499 cases, and the overall mutation rate was 14%.8 Also, EGFR mutations are more frequently detected in female patients and non-smokers.9
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