Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy

IF 7.7 1区医学 Q1 CLINICAL NEUROLOGY Annals of Neurology Pub Date : 2005-12-22 DOI:10.1002/ana.20707

Keith A. Josephs MST, MD, Jennifer L. Whitwell BA, Bradley F. Boeve MD, Maria M. Shiung BA, Jeffrey L. Gunter PhD, Joseph E. Parisi MD, Dennis W. Dickson MD, Clifford R. Jack MD

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引用次数: 33

Abstract

Objective

To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans.

Methods

This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects.

Interpretation

These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

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尸检证实进行性核上性麻痹的脑萎缩率

目的探讨6例尸检证实的进行性核上性麻痹(PSP)患者的脑萎缩率和脑室扩张率。方法采用边界移位积分法测定6例病理证实的PSP患者的脑萎缩和心室扩张率，并与6例年龄和性别匹配的对照组进行比较。结果:PSP患者的脑萎缩和心室扩张率分别为每年1.3%和7.0%，而对照组为每年0.4%和1.8%。这些比率提供了一个基准，可用于监测PSP的未来治疗反应。Ann Neurol 2006

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.