CHRONOTHERAPY – NEW POSSIBILITIES FOR OPTIMIZING TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

The article is devoted to the topical issues of the chronotherapeutic approach in the treatment of patients with hypertension (AH). Based on the review of the modern scientific sources, the data about the potential of chronotherapy as a variant of the patient-oriented approach in the treatment of AH, which can positively influence both the efficiency of hypotensive therapy and the incidence of cardiovascular complications.  Taking into account the prognostic significance of nocturnal blood pressure (BP) values, the interest in chronotherapeutic approach to prescription of hypotensive drugs in the treatment of AH has increased. Determination of the role of nocturnal BP changes as a predictor of overall cardiovascular mortality, myocardial infarction and stroke allowed to change the view on the existing traditional treatment regimen. In particular, the results of several studies have demonstrated a significant advantage of using antihypertensive drugs at night compared to the usual practice of taking all such drugs after awakening, both in terms of improving BP control and reducing the risk of cardiovascular complications and mortality.