Neurological Repair after Stroke

Abstract

Stroke remains as a major cause of human disability worldwide. Neural repair can be defined as restoring the structure or function of the CNS (central nervous system) after injury or stroke. Patients are usually left with debilitating motor and speech impairments after a stroke or injury [1]. The model is based on the assumptions of neural repair mechanisms inherently involved in the cellular and circuit plasticity, that is a synaptic phenomenon which is mostly stimulus-dependent, and that brain repair required both physical and behavioural interventions which tailor to reorganize specific brain circuits. We believe that by enhancing plasticity at the level of brain network interactions, this neurological model for brain repair could ultimately lead to a cure for stroke [2]. Several categories of therapies based on neural repair are under study. Therapies based on neural repair are based on prevention and to reduce the injury like reperfusion or neuroprotection. Therapies based on neural repair have a treatment time measured in daysweeks or longer typically and the potential to be accessed by large fraction of patients with the stroke, including haemorrhagic stroke. This is an advantage for reducing the heavy burden of individual’s disability after stroke.