{"title":"Role of organic anion transporters in xenobiotics induced toxicity","authors":"X. Xue, Li-kun Gong, Jin Ren","doi":"10.3867/J.ISSN.1000-3002.2009.03.013","DOIUrl":null,"url":null,"abstract":"It is unavoidable for body to exposure of organic anions including endogenous agents such as hormones,neurotransmitters and cellular metabolites,and xenobiotic agents such as medication,herbicides,pesticides,and plant and animal toxins. Rapid and efficient elimination of toxic substances among them is the body′s best defense. The active transepithelial transport mediated by organic anion transporters is often a rate-limiting step. Therefore,the investigations of organic anion transporters about their classification,tissue distrubution driving force,gene expression and regulatory are of great significance in toxicology.","PeriodicalId":10149,"journal":{"name":"中国药理学与毒理学杂志","volume":"23 1","pages":"237-240"},"PeriodicalIF":0.0000,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国药理学与毒理学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3867/J.ISSN.1000-3002.2009.03.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
It is unavoidable for body to exposure of organic anions including endogenous agents such as hormones,neurotransmitters and cellular metabolites,and xenobiotic agents such as medication,herbicides,pesticides,and plant and animal toxins. Rapid and efficient elimination of toxic substances among them is the body′s best defense. The active transepithelial transport mediated by organic anion transporters is often a rate-limiting step. Therefore,the investigations of organic anion transporters about their classification,tissue distrubution driving force,gene expression and regulatory are of great significance in toxicology.
中国药理学与毒理学杂志Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.20
自引率
0.00%
发文量
6787
期刊介绍：
Chinese Journal of Pharmacology and Toxicology was first published in November 1986. As a journal of high academic value jointly edited by the Chinese Pharmacological Society, Chinese Society of Toxicology and the Academy of Military Medical Sciences (AMMS), it is a dominating one in China’s biomedicine, devoted to publication of research findings, reviews of special topic and new technologies and methods in every branch of experimental toxicology and pharmacology.
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