Vitamin D receptor gene polymorphisms in Sudanese children with type 1 diabetes

Abstract

Abstract Type 1 diabetes mellitus (T1DM) is a T cell mediated autoimmune disease. Vitamin D was found to suppress the incidence of diabetes when bind to its receptor (VDR), probably by suppressing T cell activations. Thus the VDR gene polymorphism may have an impact on pathophysiology of this disease. Since there was no consistent association between VDR polymorphisms and the risk of T1DM, this study aimed to investigate a VDR gene polymorphism in Sudanese children with T1DM. We examined the VDR gene Bsm1 (rs1544410), Apa1 (rs7975232), and Taq1 (rs731236) single nucleotide polymorphisms in 174 children with T1DM, and 56 children as control, and the association of these polymorphisms with the diabetic control. Among study patients, the majority (85.63%) of diabetic patients reported metabolically poor controlled (HbA1c > 8%). As compared with the control, patients with T1DM presented more commonly with Bsm1 B allele (p = 0.001; OR 0.283; 95% CI 0.131–0.609) and Taq1 T allele (p = 0.05; OR 2.429; 95% CI 1.073–5.496). Apa1 A allele was less common in patients with T1DM without statistical difference (p = 0.862; OR 1.085; 95% CI 0.546–2.156). Our study suggests that, Bsm1 and Taq1 polymorphisms of the VDR gene associated with the prevalence of T1DM.