Ricardo Kenji Iguchi Panucci, Alex, re Mellitto, C. R. Oliveira, Welker de Mello Marin, C. Bincoletto
{"title":"In vitro Study of Anti-Leukemic Potential of Ursolic Acid in Jurkat Cell Line","authors":"Ricardo Kenji Iguchi Panucci, Alex, re Mellitto, C. R. Oliveira, Welker de Mello Marin, C. Bincoletto","doi":"10.4172/2324-9110.1000161","DOIUrl":null,"url":null,"abstract":"This study aims to assess the possible antitumor effects of the Ursolic Acid through cell death studies. Hence, Jurkat cell lines related to leukemia were subjected to treatment with different concentrations of the Ursolic Acid in order to identify their likely mechanism of death. After completion of cell viability tests, we suggest that this acid used in this study have antiproliferative/ cytotoxic activity in a dose-dependent manner. The results obtained indicate that the Ursolic Acid assessed in this study have cytotoxic activity with IC50% value of 10 μM. In addition, we observed that the IC50% value tested on the same cell line revealed a significant percentage of stagnant cells in cell cycle sub-G1 phase, a finding that allows us to infer the cytotoxic ability of the acid assessed.","PeriodicalId":73658,"journal":{"name":"Journal of clinical & experimental oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical & experimental oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2324-9110.1000161","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
This study aims to assess the possible antitumor effects of the Ursolic Acid through cell death studies. Hence, Jurkat cell lines related to leukemia were subjected to treatment with different concentrations of the Ursolic Acid in order to identify their likely mechanism of death. After completion of cell viability tests, we suggest that this acid used in this study have antiproliferative/ cytotoxic activity in a dose-dependent manner. The results obtained indicate that the Ursolic Acid assessed in this study have cytotoxic activity with IC50% value of 10 μM. In addition, we observed that the IC50% value tested on the same cell line revealed a significant percentage of stagnant cells in cell cycle sub-G1 phase, a finding that allows us to infer the cytotoxic ability of the acid assessed.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
