Comparison of anxiolytic effects of the homeopathic complex Vita-C 15 in compared with Aconitum Napellus in the acutely stressed C57BL6 mice

S. M. Liew
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引用次数: 2

Abstract

A phobias and stress are the main mental health problems among the Malaysian population, with global prevalence varying from 8% to 18%. Even so, less than 30% who suffer these disturbances seek treatment. The objective of this study is to evaluate and compare the anxiolytic effects of Aconitum napellus and homeopathic complex Vita-C 15 in the acutely stressed C57BL6 mice by using the fecal corticoid test, open field test (OFT) and c-Fos, NMDAR 2B, NPY 1R and NPY 2R activity through the hippocampus. A double blinded randomized controlled study is conducted at Animal Laboratory of Cyberjaya University College of Medical Sciences (CUCMS). All the animals are acclimatized to constant laboratory conditions for 14 days before starting the experiments. Prior to the experiment, a pilot study is performed to identify the most suitable and ideal potency for the homeopathic remedy of Aconitum napellus. The animals are tested (n=3) per group on the potency of 6C, 30C and 200C. The treatments are carried out over 9 days. 48 male C57BL6 mice (n=6), 4-5 weeks of age are used. They are randomly selected and divided into two groups. Group-1 was the healthy control group of mice which are not exposed to acute stress. Group-2 was the stress group. Comprise of mice expose to acute restraint stress. Prior to restraint stress, the treatments given are Aconitum napellus 30 cH, Homeopathic complex Vita-C 15, Diazepam and placebo. Then the results are evaluated by fecal CORT test and open field test by comparing the anxiolytics between pre-test and post-test. Aconitum napellus 30 cH and Homeopathic complex Vita-C 15 are expected to be more effective and can reduce the occurrence of anxiety in the acutely stressed C57BL6 mice. Thus, research into prevention and supportive therapies is necessary and beneficial for this disorder.
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顺势疗法复方维生素c15与乌头对急性应激C57BL6小鼠抗焦虑作用的比较
恐惧症和压力是马来西亚人口中主要的心理健康问题,全球患病率从8%到18%不等。即便如此,只有不到30%的患者寻求治疗。本研究的目的是通过粪便皮质激素试验、开放场试验(OFT)和通过海马的c-Fos、NMDAR 2B、NPY 1R和NPY 2R活性,评价和比较黑头乌及其顺势疗法复合物vita - c15对急性应激C57BL6小鼠的抗焦虑作用。在赛城大学医学院动物实验室(CUCMS)进行了一项双盲随机对照研究。实验开始前,所有动物都要适应恒定的实验室条件14天。在实验之前,进行了一项初步研究,以确定最合适和最理想的顺势疗法治疗乌头的效力。每组动物(n=3)测试6C、30C和200C的效力。治疗时间为9天。选用4-5周龄雄性C57BL6小鼠48只(n=6)。他们被随机选择并分成两组。第1组为未急性应激的健康对照组。第二组为应激组。由暴露于急性约束压力下的小鼠组成。在约束应激之前,给予的治疗是乌头30ch,顺势疗法复合维生素c - 15,安定和安慰剂。然后通过粪便CORT测试和野外测试,通过比较测试前和测试后的焦虑药物来评价结果。黑头乌头30ch和顺势疗法复合物vita - c15有望更有效地减少急性应激C57BL6小鼠焦虑的发生。因此,对这种疾病的预防和支持性治疗的研究是必要的和有益的。
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