COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure

Abstract

Chronic obstructive pulmonary disease (COPD) has been linked to air pollution exposure. Air pollution has been associated with eosinophilic inflammation of respiratory disease. The objective of this study was to determine associations between air pollution and eosinophilic inflammation in COPD. A cross-sectional study was conducted on 291 COPD patients recruited from hospitals in Taipei between January 2014 and 2021, including 147 patients with eosinophil blood count ≥ 2% and 144 patients < 2%. Land use regression (LUR) model was used to estimate exposure levels to particulate matter with an aerodynamic diameter of < 10 µ m (PM 10 ), PM 2.5 ( < 10 µ m), nitrogen oxides (NO x ) and nitrogen dioxides (NO 2 ). We investigated associations of air pollution with COPD outcomes by performing a linear regression approach. A two-pollutant approach was applied to examine the associations of PM 10 or PM 2.5 with NO x or NO 2 in COPD with eosinophilic inflammation. An increase of 1 µ g m –3 in PM 10 was associated with a 0.62% (95% CI: –1.10%, –0.13%) decrease in the forced vital capacity (FVC) in COPD. An increase of 1 µ g m –3 in PM 2.5 was associated with a 0.38% (95% CI: –0.71%, –0.05%) decrease in the FVC. A 1 µ g