Lactoferrin: A Powerful Antimicrobial Protein Present in Milk

Sarahí Luna-Castro, Luisa Samaniego-Barrón, Luis E. Serrano-Rubio, I. Ceballos-Olvera, Christian Avalos-Gómez, M. Garza
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引用次数: 5

Abstract

Lactoferrin (Lf) is an iron-chelating glycoprotein present in milk and mucosal secretions, a component of the mammalian innate immune system. Lf is microbiostatic and microbicidal. Lf can reduce the bacterial expression of virulence factors, such as those involved in biofilm production and protease secretion. The high identity among mammalian Lf sequences facilitates its use in human and veterinary medicine. Lf of bovine origin is the principal Lf used due to its commercial availability through purification from milk whey; recombinant Lfs (bovine, human, and porcine) have been used as well. Lf is a stable protein that retains its physicochemical characteristics under gastric pH conditions, and in most cases it is bioactive even after digestion; thus, the incorporation of Lf into diets facilitates its administration to animals. The aim of this review is to examine original research in which the effects of bovine and porcine Lf on pathogens of domestic animals have been demonstrated through in vitro and in vivo assays, with the purpose of ascertaining the benefits that Lf provides in the treatment of infectious diseases.
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乳铁蛋白:存在于牛奶中的一种强大的抗菌蛋白
乳铁蛋白(Lf)是存在于乳和粘膜分泌物中的一种铁螯合糖蛋白,是哺乳动物先天免疫系统的一个组成部分。它具有抑菌和杀微生物作用。它可以降低细菌表达的毒力因子,如那些参与生物膜的生产和蛋白酶分泌。哺乳动物Lf序列的高度同一性有助于其在人类和兽药中的应用。由于从乳清中提纯后可获得商业用途,因此主要使用牛源性Lf;重组Lfs(牛、人、猪)也已被使用。它是一种稳定的蛋白质,在胃pH条件下保持其物理化学特性,在大多数情况下,即使在消化后也具有生物活性;因此,在饲料中掺入铁有利于给药。本综述的目的是审查通过体外和体内试验证明牛和猪Lf对家畜病原体的影响的原始研究,目的是确定Lf在治疗传染病方面提供的益处。
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