Reduce the Neuroapoptosis in the Brain of Rats Born to Mothers with Experimental Placental Insufficiency by Combination of Thiotriazoline with L-Arginine and Thiotriazolin with Piracetam

Belenichev Igor Fedorovich, D. Voitenko, N. Bukhtiayrova
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引用次数: 1

Abstract

Our study experimentally provides promising opportunities for further clinical use of a combination of the essential amino acid L-arginine with a thiotriazoline in placental insufficiency (PI). The biological functions of L-arginine are substantiated by the fact that it is a precursor to the synthesis of nitric oxide (NO). Tiotriazolin is able to act as a tansport molecule NO, forming nitrosothiols. The pharmacological effect of the combination is due to the mutual potentiality of thiotriazoline and arginine on the synthesis, transport and bioavailability of NO and the physiological functions of this molecular messenger.
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硫代三唑啉与l -精氨酸及硫代三唑啉与吡拉西坦联用对实验性胎盘功能不全母鼠脑内神经细胞凋亡的影响
我们的实验研究为进一步临床应用必需氨基酸l -精氨酸与硫代三唑啉联合治疗胎盘功能不全(PI)提供了有希望的机会。l -精氨酸是一氧化氮(NO)合成的前体,这一事实证实了它的生物学功能。Tiotriazolin能够作为运输分子NO,形成亚硝基硫醇。该组合的药理作用是由于硫三唑啉和精氨酸对NO的合成、转运和生物利用度以及该分子信使的生理功能的相互电位。
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