Escherchia coli 敗血症に合併した Acquired Bおよび Tk-polyagglutination の1例

Abstract

We report on a patient who developed acquired B antigen and Tk polyagglutination in Escherichia coli（ Ec oli）septicaemia during the course of ulcerative colitis. In vitro analysis showed that Ec oliwas the cause of the acquired B phenomenon. The level of intensity of both Tk and acquired B antigen changed simultaneously and both disappeared at the same time. Both antigens were also abolished by acetylation of the patient’ s red blood cells. These findings indicate that the Tk polyagglutination was closely related to the acquired B antigen. H activity decreased during the course of hospitalization. From the results of acetylation of the patient’ s red blood cells the decrease in H activity was explained by the fact that acquired B‑and Tk‑expressing red blood cells showed stronger than H activity of A1 red blood cells. The antigenic modification appeared prior to the onset of Ec olisepticaemia. This finding sug‑ gests that the early detection of blood abnormalities is helpful in the early diagnosis and proper treat‑ ment of these patients.