{"title":"Potential Role of Astragaloside IV in the Treatment of Fungal Keratitis","authors":"Xiaoshuo Zheng, Wenfei Lian, Yang Liu","doi":"10.4236/abb.2022.135012","DOIUrl":null,"url":null,"abstract":"Fungal keratitis (FK) is a worldwide visual impairment disease. The pathogenesis of fungal keratitis involves fungi, corneal cells, inflammatory cell infiltration, collagen degradation, inflammatory cytokines and their interactions. Accumulated evidence indicated that Astragaloside IV (AS-IV) possesses a broad range of pharmacological properties, such as efficacy in anti-inflam-mation, alleviating fibrosis, and immunomodulatory effects. This paper sum-marizes new findings regarding AS-IV in immune and inflammatory diseases and analyzes the perspective application of Astragaloside IV in fungal keratitis.","PeriodicalId":65405,"journal":{"name":"生命科学与技术进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生命科学与技术进展(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/abb.2022.135012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Fungal keratitis (FK) is a worldwide visual impairment disease. The pathogenesis of fungal keratitis involves fungi, corneal cells, inflammatory cell infiltration, collagen degradation, inflammatory cytokines and their interactions. Accumulated evidence indicated that Astragaloside IV (AS-IV) possesses a broad range of pharmacological properties, such as efficacy in anti-inflam-mation, alleviating fibrosis, and immunomodulatory effects. This paper sum-marizes new findings regarding AS-IV in immune and inflammatory diseases and analyzes the perspective application of Astragaloside IV in fungal keratitis.
真菌性角膜炎是一种世界性的视觉损害疾病。真菌性角膜炎的发病机制涉及真菌、角膜细胞、炎性细胞浸润、胶原降解、炎性细胞因子及其相互作用。越来越多的证据表明黄芪甲苷(Astragaloside IV, as -IV)具有广泛的药理特性，如抗炎、减轻纤维化和免疫调节作用。本文综述了AS-IV在免疫性疾病和炎症性疾病中的新发现，并分析了黄芪甲苷在真菌性角膜炎中的应用前景。
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