In vitro seintransduksie meganisme uitgeoefen deur 2-etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17-een in kombinasie met ‘n dichloro-asetielsuur op die bors adenokarsinoom (MCF-7) en bors nie-tumorigene (MCF-12A) selle
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引用次数: 0
Abstract
2-Etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17 (C9) is ‘n nuwe,in silico-ontwerpte, antimitotiese 17-beta-estradiolderivaat. Dichloro-asetielsuur (DCA) inhibeer pirovaat dehydrogenase kinase ensiem aktiwiteit wat die vorming en vervoer van asetiel-KoA in die mitochondria inhibeer. Dit veroorsaak dat fermentasie prosesse, wat in kankerselle bevoordeel word, onderdruk word.
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