3D FOCALIZATION MICROFLUIDIC DEVICE BUILT WITH LTCC TECHNOLOGY FOR NANOPARTICLE GENERATION USING NANOPRECIPITATION ROUTE

Abstract

Nanoprecipitation is a nanonization technique used for nanoparticle generation. Several fields, like pharmacology and fine chemistry, make use of such technique. Typically are used a bulky batch mechanical processes rendering high polydispersity index of generated nanoparticles, poorly particle size reproducibility and energy wasting. LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical process, making it an enabling technology for the miniaturization of chemical processes. In fact, recently LTCC microfluidic reactors have been used to produce micro and nanoparticles with excellent control of size distribution and morphology. The present work provides a report on the performance of a 3D LTCC flow focusing Microfluidic device designed to fabricate polymeric nanocapsules for Hydrocortisone drug encapsulation, using nanoprecipitation route. Monodisperse Hydrocortisone nanocapsules were obtained with sizes (Tp) from 188.9 nm to 459.1 nm with polydispersity ...