{"title":"Copper Oxidation State and Mycobacterial Infection","authors":"M. Solioz","doi":"10.4172/2161-1068.1000210","DOIUrl":null,"url":null,"abstract":"Copper in aerobic environments prevails as cupric ions, Cu2+, but inside cells, is usually present as cuprous ions, Cu+. Cu+ is considerably more toxic to bacteria than Cu2+. Phagosomes employ, among other mechanisms, Cu+ to create a hostile environment for engulfed bacteria. Bacteria can reduce or oxidize copper by various mechanisms. How such reactions could affect bacterial survival in phagosomes is discussed, with a focus onMycobacteria.","PeriodicalId":74235,"journal":{"name":"Mycobacterial diseases : tuberculosis & leprosy","volume":"41 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2016-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-1068.1000210","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycobacterial diseases : tuberculosis & leprosy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2161-1068.1000210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Copper in aerobic environments prevails as cupric ions, Cu2+, but inside cells, is usually present as cuprous ions, Cu+. Cu+ is considerably more toxic to bacteria than Cu2+. Phagosomes employ, among other mechanisms, Cu+ to create a hostile environment for engulfed bacteria. Bacteria can reduce or oxidize copper by various mechanisms. How such reactions could affect bacterial survival in phagosomes is discussed, with a focus onMycobacteria.
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