{"title":"SAGES Guidelines Prevention and management of gastro-oesophageal varices and variceal haemorrhage in cirrhosis : guidelines","authors":"J. F. Botha","doi":"10.4314/SAGR.V6I1.30746","DOIUrl":null,"url":null,"abstract":"Portal hypertension, the end stage of any chronic liver disease, is caused by (1) an increased resistance to blood flow due to (a) architectural distortion of the liver by fibrous tissue and regenerative nodules (b) active intra-hepatic vaso-constriction due to decreased endogenous production of NO (2) increased portal venous inflow due to splanchnic arteriolar vasodilatation and (3) insufficient portal de-compression through collaterals which offer greater resistance to flow than does the normal liver.","PeriodicalId":39144,"journal":{"name":"South African Gastroenterology Review","volume":"6 1","pages":"23-25"},"PeriodicalIF":0.0000,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Gastroenterology Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/SAGR.V6I1.30746","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Portal hypertension, the end stage of any chronic liver disease, is caused by (1) an increased resistance to blood flow due to (a) architectural distortion of the liver by fibrous tissue and regenerative nodules (b) active intra-hepatic vaso-constriction due to decreased endogenous production of NO (2) increased portal venous inflow due to splanchnic arteriolar vasodilatation and (3) insufficient portal de-compression through collaterals which offer greater resistance to flow than does the normal liver.
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