Structural, Theoretical and Biological Studies of (Z)-3-Amino-N-(3-Amino Pyrazine-2-Carbonyl) Pyrazine-2-Carbohydrazonic Acid (APA; L) and Its Cu2+, Co2+, Pt4+ and Pd2+ Chelates

Abstract

New chelates derived from the novel ligand, (Z)-3-amino-N-(3-amino pyrazine-2-carbonyl)pyrazine-2-carbohydrazonic acid (APA, L), with Cu 2+ , Co 2+ , Pt 4+ and Pd 2+ salts were investigated. The results suggest that APA acts as mononegative tridentate in the case of Cu 2+ , binegative tetradentate in the case of Co 2+ and as mononegative bidentate towards Pt 4+ and Pd 2+ chelates. The results of the corrected µ eff . and spectral suggest the structures of the isolated chelates. The results of the corrected µ eff . and spectral suggest the geometries of the isolated chelates. Molecular modeling is deduced and chemical reactivity, energy components for chelates and also MEP for APA is illustrated. In Vitro, the SOD and radical scavengers like activity of the synthesized compounds Hep G2 liver cancer cells and cytotoxic activity were checked. Metal chelates show potent anti-oxidative activity. The results of cytotoxic activity assay against hepatocellular carcinoma cell line Hep G2 confirmed that Pt 4+ complex has the highest value, while APA, Cu 2+ , Co 2+ and Pd 2+ chelates have no significant cytotoxic activity.