Naeema Al Shibli, Azza Al Shidhani, Irfan Ullah, Hussain AlSaffar, Faris Al Kalbani, Koukab Al Farsi, Jalila Alshekaili, Nafila Al Riyami
{"title":"Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review.","authors":"Naeema Al Shibli, Azza Al Shidhani, Irfan Ullah, Hussain AlSaffar, Faris Al Kalbani, Koukab Al Farsi, Jalila Alshekaili, Nafila Al Riyami","doi":"10.5001/omj.2024.30","DOIUrl":null,"url":null,"abstract":"<p><p>Biotin is sometimes administered in mega doses to children to treat certain inborn errors of metabolism. We report the case of a one-week-old newborn who was started on a 'mitochondrial cocktail' that contained a high dose of biotin. On day seven of life, his thyroid function test showed a biochemical picture of primary hyperthyroidism, which was not clinically evident. The suspicion of immunoassay interference with thyroid function test was confirmed when another lab, using a different immunoassay, gave normal results. If the biochemical profile does not match the clinical picture, it is reasonable to doubt the test result and think of assay interference.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"4 Suppl s4 1","pages":"e679"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873207/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oman Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5001/omj.2024.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Biotin is sometimes administered in mega doses to children to treat certain inborn errors of metabolism. We report the case of a one-week-old newborn who was started on a 'mitochondrial cocktail' that contained a high dose of biotin. On day seven of life, his thyroid function test showed a biochemical picture of primary hyperthyroidism, which was not clinically evident. The suspicion of immunoassay interference with thyroid function test was confirmed when another lab, using a different immunoassay, gave normal results. If the biochemical profile does not match the clinical picture, it is reasonable to doubt the test result and think of assay interference.
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