Seda Pürnak, S. Çakmak, B. Çakır, T. Turhan, F. Artüz
{"title":"Serum Midkine Levels in Patients with Psoriasis","authors":"Seda Pürnak, S. Çakmak, B. Çakır, T. Turhan, F. Artüz","doi":"10.5336/dermato.2019-71481","DOIUrl":null,"url":null,"abstract":"functioning in the developmental period of the fetus. It was first discovered in embryonic carcinoma cells with increased expression in early stages of differentiation.1 In adults, MK is expressed in limited sites such as epidermis, kidney, lymphocytes and gut.2 MK has critical function in development and repair mechanisms in normal cells as well as tumor growth, invasion and angiogenesis in cancer cells.3,4 Various studies have shown that tumor prognosis is worse in the patients with higher MK levels.5-7 Moreover, higher serum MK levels were detected in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and Turkiye Klinikleri J Dermatol. 2020;30(1):1-5","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"30 1","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkiye Klinikleri Dermatoloji","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5336/dermato.2019-71481","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 2
Abstract
functioning in the developmental period of the fetus. It was first discovered in embryonic carcinoma cells with increased expression in early stages of differentiation.1 In adults, MK is expressed in limited sites such as epidermis, kidney, lymphocytes and gut.2 MK has critical function in development and repair mechanisms in normal cells as well as tumor growth, invasion and angiogenesis in cancer cells.3,4 Various studies have shown that tumor prognosis is worse in the patients with higher MK levels.5-7 Moreover, higher serum MK levels were detected in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and Turkiye Klinikleri J Dermatol. 2020;30(1):1-5
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