Effect of oxidative stress on development of silicosis

职业与健康 Pub Date : 2012-02-28 DOI:10.5320/WJR.V2.I1.1

R. Miao, Xue-tao Zhang, P. Guo, En-Qi He, Fangmei Zhou, D. Zhao, Ying-yi Zhang

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引用次数: 7

Abstract

[Objective]To investigate the change of indicators of oxidative stress in serum of patients with silicosis,and explore the mechanism of the development of silicosis.[Methods]Indicators of oxidative stress in serum including superoxide dismutase(SOD),nitric oxide(NO),serum glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC),nitric oxide synthase(NOS),and lipid malondialdehyde(MDA) were determined in 100 cases of control group,200 cases of dust-exposed group,32 cases of observed group(the original diagnosed 0 + patients) and 130 cases of silicosis group.[Results] Compared with the control group,NO,GSH-Px were significantly increased,and SOD were decreased significantly in dust-exposed group and silicosis group(P0.05,P0.01).Compared with the control group and dust-exposed group,T-AOC,NOS,MDA levels in silicosis group were significantly increased.(P0.05,P0.01).GSH-Px in the silicosis group was increased significantly(P0.01) than that in dust-exposed group.GSH-Px were increased in phase Ⅲ silicosis group than that in observation group and phaseⅠ silicosis group(P0.05).Pearson correlation analysis showed serum GSH-Px had a significant positive correlation with silicosis staging,grouping,seniority exposed to dust,type of work(P0.01).[Conclusion]The imbalance of oxidative and anti-oxidation system is related with the occurrence and development of silicosis.The monitoring on oxidative stress indicators is benefit for the prediction and prognosis assessment of silicosis.

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氧化应激对矽肺发展的影响

[目的]观察矽肺患者血清氧化应激指标的变化，探讨矽肺的发病机制。[方法]测定100例对照组、200例粉尘暴露组、32例观察组(原诊断0 +例)和130例矽肺组患者血清中超氧化物歧化酶(SOD)、一氧化氮(NO)、血清谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)、一氧化氮合酶(NOS)、脂质丙二醛(MDA)等氧化应激指标。[结果]与对照组比较，粉尘暴露组和矽肺组NO、GSH-Px显著升高，SOD显著降低(P0.05,P0.01)。与对照组和粉尘暴露组比较，矽肺组T-AOC、NOS、MDA水平均显著升高(P0.05,P0.01)。矽肺组GSH-Px显著高于粉尘暴露组(P0.01)。Ⅲ期矽肺病组GSH-Px明显高于观察组和Ⅰ期矽肺病组(P0.05)。Pearson相关分析显示，血清GSH-Px与矽肺分期、分型、接触粉尘工龄、工种呈正相关(P0.01)。[结论]氧化与抗氧化系统失衡与矽肺的发生发展有关。氧化应激指标的监测有利于矽肺的预测和预后评价。

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来源期刊

职业与健康医学

自引率

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发文量

38956

期刊介绍： Occupation and Health is a semimonthly journal started in 1985. It is jointly sponsored by Chinese Preventive Medicine Association and Tianjin Centers for Disease Control and Prevention, with the assistance of All-China Federation of Labor，The National Committee of Economy and Trade and Suzhou Center for Disease Control and Prevention. It is a comprehensive nation-class scientific journal of preventive medicine and openly published at home and abroad. As an all-round medical journal, the central content of Occupation and Health is occupational medicine, prevention and health care, and basic medicine, including occupational health and occupational disease control, health care, and collection, display and exchange of other scientific experiments and clinical experience, etc. Its main sections are treatise，field survey of occupational health，occupational disease and occupation-related disease; experiment, monitoring and inspection，sanitary engineering effect evaluation , food safety and nutrition, epidemiology and preventive health care, environment and health，school hygiene，etc. Occupation and Health is one of the flagship journals of Chinese Preventive Medicine Association(CPMA) . It is a national comprehensive journal of medical science distributed both in China and abroad, with published articles from various provinces, autonomous regions and cities. It has minimum publication cycle and maximum amount of information among nearly hundred kinds of CPMA series journals. Occupation and Health plays an important role in academic exchange of occupational health, preventive medicine, public health and primary health care. It has been named for the 'Outstanding Journal “ of CPMA, and also has been rated as the core journal of science and technology by Ministry of Science and Technology. Occupation and Health has been collected by China Science and Technology Statistics Source Journal, Chinese Journal Full-Length Database. A total of 346 English abstracts were collected by American Chemical Abstracts (CA) database. Occupation and Health was indexed by Chemical Abstracts Service Source Index Quarterly Supplement Introduction No.4，2009，List of 1000 Journals most frequently referenced in Chemical Abstracts (ranked 408), as well as Index Copernicus, CABI and Ulrich PD, Ulrich's Periodicals Directory.