Study of blood-ocular barrier permeability by Fluoroquinolone group drugs

Abstract

Blood-ocular barrier-specialized morphological structures that regulate the transport of fluids and substances between the vascular bed and the tissues of the eye, prohibiting the penetration of foreign cells and molecules. The permeability of various substances into the non-vascular and vascular tissues of the eye is not the same. In conditions of pathology, the blood-ocular barrier can be permeable to various endogenous, exogenous, and other substances that are not correct with respect to the cells and tissues of the eye. In this article, the permeability of the blood-ocular barrier with fluoroquinolone group drugs in the pathologies of the visual organs is considered. For this purpose, a laboratory study was conducted, during which three groups of experimental rabbits were formed (5 individuals in each group). Clinically healthy animals were included in group 1, and sick animals with experimentally induced ophthalmopathology were included in groups 2 and 3. The treatment of individuals was carried out with a solution of ciprofloxacin. A comprehensive examination of animals was carried out: clinical examination, determination of the concentration of antibacterial drugs in biological fluids, histological examination of the blood-ocular barrier, biochemical studies; hematological studies