Coagulability state in histopathologicaly and radiologicaly approved ovarian endomertiosis

Abstract

Objective: To determine the association between endometriosis and clotting abnormalities in relation to histopathological and ultrasound diagnosis. Methodology: This cross-sectional study included 125 females with endometriosis seen at Baqubah teaching hospital from April 2021 and June 2022. The women's ages varied from 21 to 43 years. Seventy-five had ultrasound-detected ovarian cysts, 48 had MRI-confirmed ovarian endometriosis, and 50 normal women served as controls. All women had thrombin time, prothrombin time, activated partial thromboplastin time, D-dimer, plasma fibrinogen, and INR tested. Results: The study had 125 females with mean age of 29±6 years. Histologically, 20.8% had endometrial gland and stroma and 11.2% had endometrial stroma. Endometriosis reduced PT, PTT, TT, and INR, but increased fibrinogen and D. dimer. There was significant association between ultrasound diagnosis and histopathological diagnosis of endometriosis. Conclusion: PT, PTT, INR, Fibrinogen, and D. dimer levels differ between histology and ultrasonography endometriosis diagnoses in women. Endometriosis patients showed greater fibrinogen and D. dimer levels and reduced PT, PTT, TT, and INR (INR).