Hematological and histopathological changes of rat's hearts experimentally infected with protoscoleces.

IF 0.8 4区医学 Q4 PARASITOLOGY Tropical biomedicine Pub Date : 2022-03-01 DOI:10.47665/tb.39.1.014

M. A. Alsaadawi, A. H. Al-Safar, A. M. Al-Yasari, H. M. Hussein, A. H. Allawi, N. Alsalih, D. A. Kalef

{"title":"Hematological and histopathological changes of rat's hearts experimentally infected with protoscoleces.","authors":"M. A. Alsaadawi, A. H. Al-Safar, A. M. Al-Yasari, H. M. Hussein, A. H. Allawi, N. Alsalih, D. A. Kalef","doi":"10.47665/tb.39.1.014","DOIUrl":null,"url":null,"abstract":"Hydatidosis; is a zoonotic disease caused by Echinococcus granulosus and characterized by infiltration of inflammatory cells. This study was investigated the hematological and histopathological changes in the hearts of rats injected with protoscoleces. Rats were injected with protoscoleces collected from either liver of sheep, goats, and cows (from the abattoir of Al-Muthanna province, south of Iraq) or isolated from infected humans from Al-Hussein Teaching Hospital. Sheep protoscoleces showed a significant increase of lymphocytes that refer to the induction of a high response of the immune system in rats. The numbers of WBC, RBCs, and platelets were generally increased in rats injected with protoscoleces isolated from sheep and goats. These changes could refer to the activation of defense mechanisms against the hydatid injected materials. However, the levels of MCV, MCH, MCHC, MPV and PDW were less than normal values. Heart sections of rats injected with protoscoleces isolated from humans showed clear histological changes. While TSP, TGP and TCP exhibited variant histopathological changes such as infiltration of inflammatory cells, pink glass appearance and congestion of arteries. Thus, these alterations can be considered as additional evidence of how the immune response reacts against the injected materials in the heart.","PeriodicalId":23476,"journal":{"name":"Tropical biomedicine","volume":"39 1 1","pages":"117-125"},"PeriodicalIF":0.8000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropical biomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47665/tb.39.1.014","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PARASITOLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Hydatidosis; is a zoonotic disease caused by Echinococcus granulosus and characterized by infiltration of inflammatory cells. This study was investigated the hematological and histopathological changes in the hearts of rats injected with protoscoleces. Rats were injected with protoscoleces collected from either liver of sheep, goats, and cows (from the abattoir of Al-Muthanna province, south of Iraq) or isolated from infected humans from Al-Hussein Teaching Hospital. Sheep protoscoleces showed a significant increase of lymphocytes that refer to the induction of a high response of the immune system in rats. The numbers of WBC, RBCs, and platelets were generally increased in rats injected with protoscoleces isolated from sheep and goats. These changes could refer to the activation of defense mechanisms against the hydatid injected materials. However, the levels of MCV, MCH, MCHC, MPV and PDW were less than normal values. Heart sections of rats injected with protoscoleces isolated from humans showed clear histological changes. While TSP, TGP and TCP exhibited variant histopathological changes such as infiltration of inflammatory cells, pink glass appearance and congestion of arteries. Thus, these alterations can be considered as additional evidence of how the immune response reacts against the injected materials in the heart.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

原头节瘤感染大鼠心脏的血液学和组织病理学变化。

包虫病;是由细粒棘球绦虫引起的一种人畜共患疾病，以炎症细胞浸润为特征。本研究观察了原头节块注射后大鼠心脏的血液学和组织病理学变化。给大鼠注射从绵羊、山羊和奶牛(来自伊拉克南部Al-Muthanna省的屠宰场)的肝脏收集的原头节，或从Al-Hussein教学医院的感染者身上分离的原头节。绵羊原头节显示淋巴细胞显著增加，这是指诱导大鼠免疫系统的高反应。大鼠注射绵羊和山羊分离的原头节后，白细胞、红细胞和血小板数量普遍增加。这些变化可能与激活了对棘球虫注入物质的防御机制有关。MCV、MCH、MCHC、MPV、PDW均低于正常值。注射人类原头节的大鼠心脏切片显示出明显的组织学变化。而TSP、TGP和TCP表现出不同的组织病理改变，如炎症细胞浸润、粉红色玻璃样和动脉充血。因此，这些改变可以被认为是免疫反应如何对抗心脏注射物质的额外证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Tropical biomedicine 医学-寄生虫学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Society publishes the Journal – Tropical Biomedicine, 4 issues yearly. It was first started in 1984. The journal is now abstracted / indexed by Medline, ISI Thompson, CAB International, Zoological Abstracts, SCOPUS. It is available free on the MSPTM website. Members may submit articles on Parasitology, Tropical Medicine and other related subjects for publication in the journal subject to scrutiny by referees. There is a charge of US$200 per manuscript. However, charges will be waived if the first author or corresponding author are members of MSPTM of at least three (3) years'' standing.