S. Murakami, F. Takayama, T. Egashira, Mitsuko Imao, A. Mori
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引用次数: 3
Abstract
Non-alcoholic
steatohepatitis (NASH) can progress to cirrhosis or hepatocellular carcinoma.
Oxidative stress is implicated in NASH progression. Fermented papaya
preparation (FPP) has oxygen radical scavenging activity and is effective in
oxidative stress-related diseases. We investigated the effects of FPP on NASH
progression using a rat NASH model. Plasma biochemical parameters and lipid
peroxidation in the liver were elevated in NASH rats. Histologically, the liver
of NASH rats showed liver fibrosis, mitochondrial dysfunction and over-expression
of microsomal CYP2E1. Myeloperoxidase activity and nuclear factor-kappaB activation
were also markedly increased in NASH. Oral administration of FPP ameliorated
these changes in NASH rats. These results suggest that FPP halts NASH
progression through its anti-oxidative and antiinflammatory properties.
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