A Selective PVC Matrix Assisted Potentiometric Sensor for the Determination of Hydroxyzine Hydrochloride (HDH)

Abstract

A membrane sensor using an ion association complex of hydroxyzine hydrochloride (HDH) with Orange II (ORG-II) dye, in a polyvinyl chloride (PVC) matrix, has been developed and used as a selective electrode for HDH quantification in pharmaceuticals. The sensor is suitable to determine 2.2 × 10 -5 - 1.1 × 10 -3 mol L -1 HDH, in the pH range from 2.5 to 5.21, with the Nernstian slope of 57.41±1.04 mV/decade, under optimum conditions. The regression coefficient (RC) value of 0.999 shows a good correlation between HDH concentration and the potential measured using the proposed sensor. The sensor limit of detection (LOD) was 4.5 × 10 -6 M. A standard-addition procedure was followed to study the effect of various interferents. The results revealed no variations caused by foreign ions or species. The regression equation (RE) and relative standard deviation (RSD) values, from 1.67 to 5, and from 1.86 to 4.81%, respectively, indicated the HDH-ORG sensor acceptable accuracy and precision. The RSD values of ≤5.67 and <5% indicated the sensor acceptable robustness and ruggedness, respectively. It has been successfully used to determine HDH in tablets, and excellent results were obtained.