{"title":"Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals","authors":"S. Ramukutty, E. Ramachandran","doi":"10.4236/JCPT.2014.42010","DOIUrl":null,"url":null,"abstract":"Kinetics of the decomposition of racemic ibuprofen crystals were studied \nby non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen \nis thermally stable up to 152.6°C and the initial loss of mass was due to \nevaporation only. Activation energy, pre-exponential factor, activation entropy \nand Gibbs free energy for the decomposition of ibuprofen were determined using \nthe integral method of Coats-Redfern (CR). Geometrical contraction models were \nfound to be the best fits. The Arrheinus equation for the thermal decomposition \nof ibuprofen is k = (1.1 × 107) e–79125/RT sec–1.","PeriodicalId":64440,"journal":{"name":"结晶过程及技术期刊(英文)","volume":"04 1","pages":"71-78"},"PeriodicalIF":0.0000,"publicationDate":"2014-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"32","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"结晶过程及技术期刊(英文)","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.4236/JCPT.2014.42010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 32
Abstract
Kinetics of the decomposition of racemic ibuprofen crystals were studied
by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen
is thermally stable up to 152.6°C and the initial loss of mass was due to
evaporation only. Activation energy, pre-exponential factor, activation entropy
and Gibbs free energy for the decomposition of ibuprofen were determined using
the integral method of Coats-Redfern (CR). Geometrical contraction models were
found to be the best fits. The Arrheinus equation for the thermal decomposition
of ibuprofen is k = (1.1 × 107) e–79125/RT sec–1.
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