Renal predictors of mortality in stroke patients: partial results of a transversal study

Abstract

Introduction: Renal factors are known as important, and a controllable factor, to define prognosis,mortality and hospitalization time in most of diseases. It still lacks studies that clarify in a specific way the role of this factors. Objectives: This study aims to elucidate the impact of renal factor in outcomes of stroke patients (hospitalization time, CTI time, delirium, infection and death during internment). Methods: We performed a transversal study, part of a cohort. Data of previous renal insufficiency,admission,highest and last creatinine and urea and the highest creatinine clearance during hospitalization. We performed univariate analysis, with T test, Mann-Whitney or chi-square tests;after, multivariate analysis with logistic regression (considering P < 0.05). Results: We obtained 190 patients. Admission creatinine was significant to death (P = 0.05), delirium (P = 0.07) and infection (P = 0.06); highest creatinine to hospitalization time, delirium, infection (P < 0.001) and death (P = 0.008);and last creatinine to death (P < 0.001), delirium (P = 0.003), infection (P = 0.01) and CTI time (P = 0.1). Previous renal insufficiency showed significance to death (P = 0.03), delirium and infection (P < 0.001). ). Highest urea showed significance to all outcomes (P < 0.001), including CTI time (P = 0.004); admission urea to death (P = 0.01); and last urea to death (P < 0.001), hospitalization time (P = 0.1) and delirium (P = 0.06). Clearance only did not show significance to CTI time.Multivariate analysis to each outcome obtained: last creatinine to death (P = 0.03); highest creatinine to hospitalization time (P = 0.02); admission (P = 0.01), highest (P = 0.01) creatinine, admission urea (P = 0.03) and clearance (P = 0.01) to delirium; renal insufficiency (P = 0.009), admission (P = 0.007), highest (P = 0.002) and last (P = 0.02) creatinine, highest urea (P = 0.005) and clearance (P = 0.003). None was significant to CTI time. Conclusion: All parameters of renal function showed to be important measures of prognosis in stroke patients; thus, it is a factor we need to be aware of during hospitalization time.