{"title":"Computational models of Alzheimer's disease","authors":"Vassilis Cutsuridis, A. Moustafa","doi":"10.4249/scholarpedia.32144","DOIUrl":null,"url":null,"abstract":"There have been a few attempts to design computational models of AD. Some of these models focus on hippocampus function yet many suffer from simulating exact effects of amyloid plaques and neurofibrillary tangles. See Duch (2007) for a review of some AD models. Below, we discuss biochemical, single cell, biophysical spiking, and systems-level and abstract models of AD.","PeriodicalId":74760,"journal":{"name":"Scholarpedia journal","volume":"12 1","pages":"32144"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scholarpedia journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4249/scholarpedia.32144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
There have been a few attempts to design computational models of AD. Some of these models focus on hippocampus function yet many suffer from simulating exact effects of amyloid plaques and neurofibrillary tangles. See Duch (2007) for a review of some AD models. Below, we discuss biochemical, single cell, biophysical spiking, and systems-level and abstract models of AD.
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