{"title":"The importance of acetaldehydein the metabolism and mechanismof ethyl alcohol action","authors":"W. Dyr, E. Wyszogrodzka","doi":"10.5114/ain.2018.83913","DOIUrl":null,"url":null,"abstract":"Acetaldehyde is the first metabolite of ethanol and may be formed by alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1) and catalase. ADH is an essential pathway that oxidises alcohol in peripheral tissues (primarily in the liver). Acetaldehyde is oxidised to acetic acid by the aldehyde dehydrogenase (ALDH) enzyme. Acetaldehyde passes into the brain from the peripheral blood with difficulty, due to the blood-brain metabolic barrier, which is ALDH in the brain blood vessels. Acetaldehyde can be formed directly in the brain, mainly by catalase enzyme. Another important enzyme metabolising ethanol in central nervous system is CYP2E1. The gene mutation (ALDH2*2) causes an increase in the level of acetaldehyde in the blood Streszczenie","PeriodicalId":42147,"journal":{"name":"Alkoholizm i Narkomania-Alchoholism and Drug Addition","volume":"31 1","pages":"301-314"},"PeriodicalIF":0.1000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/ain.2018.83913","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alkoholizm i Narkomania-Alchoholism and Drug Addition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/ain.2018.83913","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 0
Abstract
Acetaldehyde is the first metabolite of ethanol and may be formed by alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1) and catalase. ADH is an essential pathway that oxidises alcohol in peripheral tissues (primarily in the liver). Acetaldehyde is oxidised to acetic acid by the aldehyde dehydrogenase (ALDH) enzyme. Acetaldehyde passes into the brain from the peripheral blood with difficulty, due to the blood-brain metabolic barrier, which is ALDH in the brain blood vessels. Acetaldehyde can be formed directly in the brain, mainly by catalase enzyme. Another important enzyme metabolising ethanol in central nervous system is CYP2E1. The gene mutation (ALDH2*2) causes an increase in the level of acetaldehyde in the blood Streszczenie
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